H. Courtney Hodges

Feb 13, 2024 | nature.com | Chandra sekhar amara |Andrea B. Apolo |Jianjun Gao |Yair Lotan |H. Courtney Hodges |Seth P Lerner | +5 more

AbstractSMARCB1 loss has long been observed in many solid tumors. However, there is a need to elucidate targetable pathways driving growth and metastasis in SMARCB1-deficient tumors. Here, we demonstrate that SMARCB1 deficiency, defined as genomic SMARCB1 copy number loss associated with reduced mRNA, drives disease progression in patients with bladder cancer by engaging STAT3. SMARCB1 loss increases the chromatin accessibility of the STAT3 locus in vitro.