Hai Feng Zhang

Dec 4, 2024 | nature.com | Xiangjie Leng |Ruijie Shi |Zhaorui Xu |Hai Feng Zhang |Wenxuan Xu |Xuejing Lu | +1 more

Diabetic macular edema (DME) is a common complication of diabetes that can lead to vision loss, and anti-vascular endothelial growth factor (anti-VEGF) therapy is the standard of care for DME, but the treatment outcomes vary widely among patients. This study collected optical coherence tomography (OCT) images and clinical data from DME patients who received anti-VEGF treatment to develop and validate deep learning (DL) models for predicting the anti-VEGF outcomes in DME patients based on convolutional neural network (CNN) and multilayer perceptron (MLP) combined architecture by using multimodal data. An Xception-MLP architecture was utilized to predict best-corrected visual acuity (BCVA), central subfield thickness (CST), cube volume (CV), and cube average thickness (CAT). Mean absolute error (MAE), mean squared error (MSE) and mean squared logarithmic error (MSLE) were employed to evaluate the model performance. In this study, both the training set and the validation set exhibited a consistent decreasing trend in MAE, MSE, and MSLE. No statistical difference was found between the actual and predicted values in all clinical indicators. This study demonstrated that the improved CNN-MLP regression models using multimodal data can accurately predict outcomes in BCVA, CST, CV, and CAT after anti-VEGF therapy in DME patients, which is valuable for ophthalmic clinical decisions and reduces the economic burden on patients.

Aug 14, 2023 | nature.com | Wei Li |Hai Feng Zhang

AbstractThe earliest ceramic drainage system unearthed at the Pingliangtai site on the Central Plains of China represents an unprecedented social and environmental manipulation as societies faced surging environmental crises in the Late Holocene East Asian Monsoon region. Here we present results of excavation and a geoarchaeological survey of the water-management infrastructures and environment which reveal the operation and maintenance of a well-planned and regulated two-tiered drainage system.

Apr 12, 2023 | blogs.sap.com | Hai Feng Zhang

The SAP HANA supportability toolset provides a consolidated set of tools for performance analysis and troubleshooting. The tool is available as an extension for Microsoft Visual Studio Code and includes a range of reports that can be used for online and offline analysis. Key ValueSimpleThe tool integrates SAP HANA database knowledge from SAP notes and SAP HANA database experts. User could analyze HANA Database related issue much easier.