
Articles
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2 weeks ago |
nature.com | Wei Li
Obligate mobile element guided activity is a class of RNA-guided nucleases such as IscB, the ancestor of Cas9. IscB has been used for genome editing, owing to its small size and large structured guiding RNA (ωRNA). Genome editors with improved activity and specificity have been crucial for biological applications. Kannan et al. introduced an optimized variant, NovaIscB, by combining large-scale ortholog screening and evolution- and structure-guided protein engineering.
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1 month ago |
pubs.acs.org | Fangjie Wang |Sheng-Li Niu |Wei Li |Hong-yuan Liu
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1 month ago |
nature.com | Wei Li
Living ape species are close evolutionary relatives of humans and their genomes are essential for human genomic and evolutionary studies. Yoo et al. generated complete genome assemblies of six ape species: chimpanzee (Pan troglodytes), bonobo (Pan paniscus), gorilla (Gorilla gorilla), Bornean orangutan (Pongo pygmaeus), Sumatran orangutan (Pongo abelii) and siamang (Symphalangus syndactylus). For diploid genomes, 74% of all chromosomes were assembled telomere-to-telomere.
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1 month ago |
pubs.acs.org | Xiaotong Li |Wei Li |Zhanyun Wang |Xianfeng Wang
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1 month ago |
dx.doi.org | Xiaotong Li |Wei Li |Zhanyun Wang |Xianfeng Wang
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