Hai Huang

Oct 21, 2024 | pubs.acs.org | Wentong Zhang |Hai Huang |Miao Li |Zhengfu Ning

1. IntroductionClick to copy section linkSection link copied!CO2, as a major component of greenhouse gases, has garnered much attention. Since the industrial revolution, more emitted CO2 molecules have caused the temperature to rise gradually, leading to a dramatic influence on the ecological system and global climate change. These impacts included global warming, rising sea levels, and land desertification, which imposes severe threats to human life.

Oct 21, 2024 | dx.doi.org | Wentong Zhang |Hai Huang |Miao Li |Zhengfu Ning

Aug 16, 2024 | nature.com | Hai Huang

AbstractGastric cancer (GC) remains a global disease with a high mortality rate, the lack of effective treatments and the high toxicity of side effects are primary causes for its poor prognosis. Hence, urgent efforts are needed to find safe and effective therapeutic strategies. Gypenoside (Gyp) is a widely used natural product that regulates blood glucose to improve disease progression with few toxic side effects.

Aug 12, 2024 | mdpi.com | Qianqian Ren |Hai Huang |Haizhu Wang |Yong Zheng

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Jun 22, 2024 | nature.com | Quanfu Li |Yiyang Liu |Jingxian Wu |Zewen Zhu |Jianjun Fan |Linhui Zhai | +10 more

Aberrations in the Hedgehog (Hh) signaling pathway are significantly prevailed in various cancers, including B-cell lymphoma. A critical facet of Hh signal transduction involves the dynamic regulation of the suppressor of fused homolog (SUFU)-glioma-associated oncogene homolog (GLI) complex within the kinesin family member 7 (KIF7)-supported ciliary tip compartment. However, the specific post-translational modifications of SUFU-GLI complex within this context have remained largely unexplored. Our study reveals a novel regulatory mechanism involving prolyl 4-hydroxylase 2 (P4HA2), which forms a complex with KIF7 and is essential for signal transduction of Hh pathway. We demonstrate that, upon Hh pathway activation, P4HA2 relocates alongside KIF7 to the ciliary tip. Here, it hydroxylates SUFU to inhibit its function, thus amplifying the Hh signaling. Moreover, the absence of P4HA2 significantly impedes B lymphoma progression. This effect can be attributed to the suppression of Hh signaling in stromal fibroblasts, resulting in decreased growth factors essential for malignant proliferation of B lymphoma cells. Our findings highlight the role of P4HA2-mediated hydroxylation in modulating Hh signaling and propose a novel stromal-targeted therapeutic strategy for B-cell lymphoma.