Yiyang Liu

Oct 11, 2024 | mdpi.com | Yiyang Liu |Jue Wang

1. IntroductionThe urgency to address climate change has prompted a global surge in the adoption of carbon reduction measures. As the leading emitter of carbon dioxide, China has proactively engaged with international demands through its “dual-carbon” strategy, targeting a peak in carbon emissions by 2030 and carbon neutrality by 2060.

Sep 24, 2024 | bmjopen.bmj.com | Jiayi Chen |Xiaonan Xu |Yiyang Liu |Carla Zi Cai

General practice / Family practice Investigations and referral for suspected gastric cancer by primary care physicians: a cross-sectional study in Southeastern China Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Jun 22, 2024 | nature.com | Quanfu Li |Yiyang Liu |Jingxian Wu |Zewen Zhu |Jianjun Fan |Linhui Zhai | +10 more

Aberrations in the Hedgehog (Hh) signaling pathway are significantly prevailed in various cancers, including B-cell lymphoma. A critical facet of Hh signal transduction involves the dynamic regulation of the suppressor of fused homolog (SUFU)-glioma-associated oncogene homolog (GLI) complex within the kinesin family member 7 (KIF7)-supported ciliary tip compartment. However, the specific post-translational modifications of SUFU-GLI complex within this context have remained largely unexplored. Our study reveals a novel regulatory mechanism involving prolyl 4-hydroxylase 2 (P4HA2), which forms a complex with KIF7 and is essential for signal transduction of Hh pathway. We demonstrate that, upon Hh pathway activation, P4HA2 relocates alongside KIF7 to the ciliary tip. Here, it hydroxylates SUFU to inhibit its function, thus amplifying the Hh signaling. Moreover, the absence of P4HA2 significantly impedes B lymphoma progression. This effect can be attributed to the suppression of Hh signaling in stromal fibroblasts, resulting in decreased growth factors essential for malignant proliferation of B lymphoma cells. Our findings highlight the role of P4HA2-mediated hydroxylation in modulating Hh signaling and propose a novel stromal-targeted therapeutic strategy for B-cell lymphoma.

May 8, 2024 | mdpi.com | Yiyang Liu |Sheng Wang |Qin Wang |Liping Wang

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Apr 22, 2024 | mdpi.com | Ying Wang |Yiyang Liu

1. IntroductionWith the acceleration of industrialization, urbanization, and globalization, environmental challenges, especially in developing countries like China, have become increasingly prominent (Ali et al., 2023; Hojnik and Ruzzier, 2016; Sherazi et al., 2024) [,,]. Rising temperatures, escalating wastewater discharge, and depletion of resources pose significant threats to sustainable development (Munawar et al., 2022; Sharif et al., 2023) [,].