Hai-Long Piao

Jan 6, 2025 | nature.com | Hai-Long Piao

Correction to: Cell Death and Disease https://doi.org/10.1038/s41419-024-06563-3, publish!ng19ed online 27 February 2024We are willing to recognize and correct our mistakes and provide the correct results to our readers. And we want to emphasize that these errors occurred during the image assembly stage, and we take full responsibility for them. We have now replaced the images with the corrected versions, and we have thoroughly cross-checked the original data to ensure the accuracy. (Figs.

Apr 12, 2024 | nature.com | Wen Wang |Yulong Wang |Hai-Long Piao

AbstractAlthough papillary thyroid cancer (PTC) has a good prognosis, its recurrence rate is high and remains a core concern in the clinic. Molecular factors contributing to different recurrence risks (RRs) remain poorly defined. Here, we perform an integrative proteogenomic and metabolomic characterization of 102 Chinese PTC patients with different RRs. Genomic profiling reveals that mutations in MUC16 and TERT promoter as well as multiple gene fusions like NCOA4-RET are enriched by the high RR.

Feb 26, 2024 | nature.com | Hai-Long Piao

AbstractImmunotherapy has become a prominent first-line cancer treatment strategy. In non-small cell lung cancer (NSCLC), the expression of PD-L1 induces an immuno-suppressive effect to protect cancer cells from immune elimination, which designates PD-L1 as an important target for immunotherapy. However, little is known about the regulation mechanism and the function of PD-L1 in lung cancer.

Jul 24, 2023 | nature.com | Hai-Long Piao

MPLCs PatientsFour patients with synchronous two lung lesions undergone R0 surgical resection in Liaoning Cancer Hospital & Institute between December 2020 and November 2021 were collected. None of them had received neoadjuvant radiotherapy, chemotherapy or immunotherapy before surgical resection. All patients were preoperatively diagnosed as MPLCs based on HRCT [45] by a multidisciplinary team (MTD) including a radiologist, thoracic surgeon, and oncologist.

Jun 16, 2023 | mdpi.com | Yuri Lee |Hai-Long Piao |Jongchan Kim

Abstract:The Wnt signaling pathway plays a critical role in regulating normal cellular processes, including proliferation, differentiation, and apoptosis. Dysregulation of Wnt signaling has been implicated in various human diseases, including cancer. β-catenin and LEF1 are key mediators of Wnt signaling, and their dysregulation is a hallmark of many cancer types.