Hailey Wallace

Mar 30, 2024 | pubs.rsc.org | Hailey Wallace |Hyunjun Yang |Sophia Tan

De novo design of peptides that bind specific conformers of α-synuclein† Insoluble amyloids rich in cross-β fibrils are observed in a number of neurodegenerative diseases. Depending on the clinicopathology, the amyloids can adopt distinct supramolecular assemblies, termed conformational strains. However, rapid methods to study amyloids in a conformationally specific manner are lacking.

Nov 16, 2023 | biorxiv.org | Hailey Wallace |Hyunjun Yang |Sophia Tan |Henry Pan

AbstractInsoluble amyloids rich in cross-beta fibrils are observed in a number of neurodegenerative diseases. Depending on the clinicopathology, the amyloids can adopt distinct supramolecular assemblies, termed conformational strains. However, rapid methods to study amyloid in a conformationally specific manner are lacking. We introduce a novel computational method for de novo design of peptides that tile the surface of alpha-synuclein fibrils in a conformationally specific manner.