Sophia Tan

Aug 27, 2024 | pubs.acs.org | Lee Schnaider |Sophia Tan |Pratik Singh |Floriana Capuano

Jul 24, 2024 | medrxiv.org | Sophia Tan |Isabel Rodriguez-Barraquer |Ada Kwan |Seth Blumberg

JAL has received grants, honoraria, and speaker fees from Pfizer; grants and honoraria from Merck, Sharp, & Dohme; honoraria from Valneva; and honoraria from VaxCyte; all unrelated to the subject of this work. ATK and DS received funding from California Prison Health Care Receivership. The remaining authors have no disclosures.

Mar 30, 2024 | pubs.rsc.org | Hailey Wallace |Hyunjun Yang |Sophia Tan

De novo design of peptides that bind specific conformers of α-synuclein† Insoluble amyloids rich in cross-β fibrils are observed in a number of neurodegenerative diseases. Depending on the clinicopathology, the amyloids can adopt distinct supramolecular assemblies, termed conformational strains. However, rapid methods to study amyloids in a conformationally specific manner are lacking.

Feb 26, 2024 | fiercebiotech.com | Sophia Tan

By Sophia Tan, PhD, Partner at The Dedham Group LLCIn the realm of oncology, the advent of clinical pathways has gained substantial traction in the past two decades as the increasing cost and complexity of cancer care demanded structured, multidisciplinary, and cost-effective approaches.

Nov 16, 2023 | biorxiv.org | Hailey Wallace |Hyunjun Yang |Sophia Tan |Henry Pan

AbstractInsoluble amyloids rich in cross-beta fibrils are observed in a number of neurodegenerative diseases. Depending on the clinicopathology, the amyloids can adopt distinct supramolecular assemblies, termed conformational strains. However, rapid methods to study amyloid in a conformationally specific manner are lacking. We introduce a novel computational method for de novo design of peptides that tile the surface of alpha-synuclein fibrils in a conformationally specific manner.