Haiping Hao

Oct 9, 2024 | biorxiv.org | José Abril |Haiping Hao |John Donohue |Kuo-Chieh Liao

AbstractRecognition of the intron branchpoint during spliceosome assembly is a multistep process that defines both mRNA structure and amount. A branchpoint sequence motif UACUAAC is variably conserved in eukaryotic genomes, but in some organisms more than one protein can recognize it. Here we show that SF1 and Quaking (QKI) compete for a subset of intron branchpoints with the sequence ACUAA.

Mar 11, 2024 | sciencedirect.com | Hui Ye |Haiping Hao

Antibiotic resistance has become one of the greatest challenges to human health as indicated by the worldwide emergence of multidrug-resistant bacteria. The “One Health” concept underscores that environment health is an important part to safeguard human health (Destoumieux-Garzon et al., 2018). ARGs have been recognized as a new class of environmental contaminants (Pruden et al., 2006), and aquatic environments serve as significant reservoir for ARGs (Yang et al., 2018).