Kuo-Chieh Liao

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An ancient competition for the conserved branchpoint sequence influences physiological and evolutionary outcomes in splicing

Oct 9, 2024 | biorxiv.org | José Abril |Haiping Hao |John Donohue |Kuo-Chieh Liao

AbstractRecognition of the intron branchpoint during spliceosome assembly is a multistep process that defines both mRNA structure and amount. A branchpoint sequence motif UACUAAC is variably conserved in eukaryotic genomes, but in some organisms more than one protein can recognize it. Here we show that SF1 and Quaking (QKI) compete for a subset of intron branchpoints with the sequence ACUAA.

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