Hamdam Hourfar

Oct 22, 2023 | biorxiv.org | Farhang Aliakbari |Daniel Otzen |Kimia Marzookian |Hamdam Hourfar

AbstractThe blood-brain barrier (BBB) is a highly developed endothelial microvessel network extended to almost all parts of the central nervous system (CNS) that tightly seals cell-to-cell contacts and plays a critical role in maintaining CNS homeostasis. It also protects neurons from factors present in systemic circulation and prevents pathogens from entering the brain. Conversely, BBB disruption can initiate multiple pathways of nerve damage.