Hang Xing

Dec 23, 2024 | pubs.rsc.org | Hang Xing

Chemistries on the Inner Leaflet of Cell Membrane The cell membrane, characterized by its inherent asymmetry, functions as a dynamic barrier that regulates numerous cellular activities. This Highlight aims to provide the chemistry community with a comprehensive overview of the intriguing and underexplored inner leaflet, encompassing both fundamental biology and emerging synthetic modification strategies.

Sep 8, 2024 | onlinelibrary.wiley.com | Yu Chi Liu |Hang Xing |Yan Zhang |Yi SONG

Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description jnr25380-sup-0001-Supplementary_Material_1.docxWord 2007 document , 24.4 KB DATA S1. Transparent Science Questionnaire for Authors DATA S2. jnr25380-sup-0002-Supplementary_Table_1.docxWord 2007 document , 22.3 KB TABLE S1. Newcastle-Ottawa Scale scores for studies included in network meta-analysis of endocannabinoid system in Alzheimer’s disease.

Dec 8, 2023 | pubs.rsc.org | Ran Liu |Zheng Liu |Mohan Chen |Hang Xing

Cooperatively designed aptamer-PROTACs for spatioselective degradation of nucleocytoplasmic shuttling protein for enhanced combinational therapy† Nucleocytoplasmic shuttling proteins (NSPs) have emerged as a promising class of therapeutic targets for many diseases. However, most NSPs-based therapies largely rely on small-molecule inhibitors with limited efficacy and off-target effects.

Nov 28, 2023 | pubs.rsc.org | Ran Liu |Zheng Liu |Mohan Chen |Hang Xing

Cooperatively Designed Aptamer-PROTACs for Spatioselective Degradation of Nucleocytoplasmic Shuttling Protein for Enhanced Combinational Therapy Nucleocytoplasmic shuttling proteins (NSPs) has emerged as a promising class of therapeutic targets for many diseases. However, most NSPs-based therapies largely rely on small-molecule inhibitors with limited efficacy and off-target effects.

Sep 12, 2023 | nature.com | Hang Xing

AbstractSynthetic polypeptides have emerged as versatile tools in both materials science and biomedical engineering due to their tunable properties and biodegradability. While the advancements of N-carboxyanhydride (NCA) ring-opening polymerization (ROP) techniques have aimed to expedite polymerization and reduce environment sensitivity, the broader implications of such methods remain underexplored, and the integration of ROP products with other materials remains a challenge.