Yi SONG

Jan 22, 2025 | mdpi.com | Kun Zheng |Zhiyuan Sun |Yi SONG |Chen Zhang

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Oct 16, 2024 | mdpi.com | Yi SONG |Shiyu Wang |Yan Xu

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Oct 8, 2024 | preprints.org | Yi SONG |Shiyu Wang |Yan Xu

Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 4 October 2024 / Approved: 7 October 2024 / Online: 8 October 2024 (09:40:50 CEST) Song, Y.; Wang, S.; Xu, Y. Mirror-Image RNA: A Right-Handed Z-Form RNA and Its Ligand Complex. Preprints 2024, 2024100457. https://doi.org/10.20944/preprints202410.0457.v1 Song, Y.; Wang, S.; Xu, Y. Mirror-Image RNA: A Right-Handed Z-Form RNA and Its Ligand Complex. Preprints 2024, 2024100457.

Oct 4, 2024 | nature.com | Yi SONG |Jian Li |Yuzhang Wu

Autoimmune disorders are characterized by aberrant T cell and B cell reactivity to the body’s own components, resulting in tissue destruction and organ dysfunction. Autoimmune diseases affect a wide range of people in many parts of the world and have become one of the major concerns in public health. In recent years, there have been substantial progress in our understanding of the epidemiology, risk factors, pathogenesis and mechanisms of autoimmune diseases. Current approved therapeutic interventions for autoimmune diseases are mainly non-specific immunomodulators and may cause broad immunosuppression that leads to serious adverse effects. To overcome the limitations of immunosuppressive drugs in treating autoimmune diseases, precise and target-specific strategies are urgently needed. To date, significant advances have been made in our understanding of the mechanisms of immune tolerance, offering a new avenue for developing antigen-specific immunotherapies for autoimmune diseases. These antigen-specific approaches have shown great potential in various preclinical animal models and recently been evaluated in clinical trials. This review describes the common epidemiology, clinical manifestation and mechanisms of autoimmune diseases, with a focus on typical autoimmune diseases including multiple sclerosis, type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, and sjögren’s syndrome. We discuss the current therapeutics developed in this field, highlight the recent advances in the use of nanomaterials and mRNA vaccine techniques to induce antigen-specific immune tolerance.

Sep 8, 2024 | onlinelibrary.wiley.com | Yu Chi Liu |Hang Xing |Yan Zhang |Yi SONG

Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description jnr25380-sup-0001-Supplementary_Material_1.docxWord 2007 document , 24.4 KB DATA S1. Transparent Science Questionnaire for Authors DATA S2. jnr25380-sup-0002-Supplementary_Table_1.docxWord 2007 document , 22.3 KB TABLE S1. Newcastle-Ottawa Scale scores for studies included in network meta-analysis of endocannabinoid system in Alzheimer’s disease.