Hangfeng Li

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Chip-Based 3D Interferometric Nanoscopy

3 weeks ago | biorxiv.org | Wei Wang |Hangfeng Li |Yilin Wang |Samuel Barnett

AbstractUltra-high resolution 3D single-molecule localization microscopy (SMLM) traditionally requires complex dual-objective lenses (4Pi) configurations to enhance axial (z) precision through interferometry. Here we present a streamlined chip-based alternative, Silicon-assisted interferometric Localization Microscopy (SiLM), which achieves comparable performance using a single-objective lens design.

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