Hanjie Wang

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Articles

Geometry of Braided DNA Dictates Supercoiling Partition

Oct 11, 2024 | biorxiv.org | Yifeng Hong |Hanjie Wang |Michelle Wang

AbstractDuring DNA replication, the replisome must rotate relative to the DNA substrate, generating supercoiling that must be partitioned in front of or behind the replisome. Supercoiling partitioned behind the replisome may intertwine (or braid) daughter DNA molecules and restrict chromosome segregation. Supercoiling partitioning and torsional resistance at the replisome should depend on the geometry of the two daughter DNA molecules, determined by their end separations.

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