Hanna Chen

Oct 19, 2023 | nature.com | Hanna Chen |Lin Zhong |Tao Lin Sun |Yiming Zhao

AbstractThe broad bioactivities of nonribosomal peptides rely on increasing structural diversity. Genome mining of the Burkholderiales strain Schlegelella brevitalea DSM 7029 leads to the identification of a class of dodecapeptides, glidonins, that feature diverse N-terminal modifications and a uniform putrescine moiety at the C-terminus. The N-terminal diversity originates from the wide substrate selectivity of the initiation module.