Hannah E. Augustijn

Jun 11, 2024 | biorxiv.org | Hannah E. Augustijn |Zachary L. Reitz |Le Fu Zhang |Jeanine A. Boot

AbstractBacteria produce a plethora of natural products that are in clinical, agricultural and biotechnological use. Genome mining revealed millions of biosynthetic gene clusters (BGCs) that encode their biosynthesis, and the major challenge is to predict the bioactivities of the molecules these BGCs specify, and how to elicit their expression.

Feb 13, 2023 | nature.com | Victòria Pascal Andreu |Hannah E. Augustijn |Lianmin Chen |Alexandra Zhernakova |Jingyuan Fu |Michael Fischbach | +1 more

AbstractThe gut microbiota produce hundreds of small molecules, many of which modulate host physiology. Although efforts have been made to identify biosynthetic genes for secondary metabolites, the chemical output of the gut microbiome consists predominantly of primary metabolites.