Hannah Hillman

Sep 23, 2023 | biorxiv.org | Michael Patterson |Victoria Osinski |Yingzheng Xu |Hannah Hillman

AbstractObjective: Trem2, a surface lipid receptor, is expressed on foamy macrophages within atherosclerotic lesions and regulates cell survival, proliferation, and anti-inflammatory responses. Studies examining the role of Trem2 in atherosclerosis have shown that deletion of Trem2 leads to impaired foamy macrophage lipid uptake, proliferation, survival, and cholesterol efflux.