Yingzheng Xu

Jun 13, 2024 | insight.jci.org | JCI Insight |Yingzheng Xu |Michael Patterson |Bastien Dolfi

ResearchEndocrinologyImmunologyOpen Access | 10.1172/jci.insight.174746 JCI Insight. https://doi.org/10.1172/jci.insight.174746. Copyright © 2024, Xu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Sep 23, 2023 | biorxiv.org | Michael Patterson |Victoria Osinski |Yingzheng Xu |Hannah Hillman

AbstractObjective: Trem2, a surface lipid receptor, is expressed on foamy macrophages within atherosclerotic lesions and regulates cell survival, proliferation, and anti-inflammatory responses. Studies examining the role of Trem2 in atherosclerosis have shown that deletion of Trem2 leads to impaired foamy macrophage lipid uptake, proliferation, survival, and cholesterol efflux.