Hansen Kosasih

Nov 5, 2024 | nature.com | Hansen Kosasih |Chelsea Mayoh |Michelle Henderson |Toby Trahair |Adam Patterson

AbstractT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that expresses high levels of the enzyme aldo-keto reductase family 1 member C3 (AKR1C3). To exploit this finding, we developed a novel prodrug, ACHM-025, which is selectively activated by AKR1C3 to a nitrogen mustard DNA alkylating agent.