Haonan Xiao

Nov 6, 2023 | nature.com | Hangtian Guo |Haonan Xiao |Yan Gao |Yun Zhu |Fei Sun

Dear Editor, In the nematode Caenorhabditis elegans, the systemic RNA interference defective protein 1 (SID-1) plays a crucial role in systemic RNA interference (RNAi) by facilitating the transport of exogenous double-stranded RNA (dsRNA) into the cytoplasm.1 Human SIDT1 and SIDT2 are closely related members of the SID-1 transmembrane family, and have been implicated in various biological processes such as glucose and lipid metabolism, innate immunity, and tumorigenesis.2,3,4,5,6 SIDT1...