Harold M. McNamara

Oct 2, 2024 | nature.com | Harold M. McNamara |Sabrina C Solley |Britt Adamson |Michelle Chan

AbstractAggregates of stem cells can break symmetry and self-organize into embryo-like structures with complex morphologies and gene expression patterns. Mechanisms including reaction-diffusion Turing patterns and cell sorting have been proposed to explain symmetry breaking but distinguishing between these candidate mechanisms of self-organization requires identifying which early asymmetries evolve into subsequent tissue patterns and cell fates.