Sabrina C Solley

Oct 2, 2024 | nature.com | Harold M. McNamara |Sabrina C Solley |Britt Adamson |Michelle Chan

AbstractAggregates of stem cells can break symmetry and self-organize into embryo-like structures with complex morphologies and gene expression patterns. Mechanisms including reaction-diffusion Turing patterns and cell sorting have been proposed to explain symmetry breaking but distinguishing between these candidate mechanisms of self-organization requires identifying which early asymmetries evolve into subsequent tissue patterns and cell fates.

Apr 3, 2024 | nature.com | Jun Yan |Purnima Ravisankar |Yangwode Jing |Weihao Yan |Ralf Schmidt |Sabrina C Solley | +4 more

AbstractPrime editing enables the precise modification of genomes through reverse transcription of template sequences appended to the 3′ ends of CRISPR–Cas guide RNAs1. To identify cellular determinants of prime editing, we developed scalable prime editing reporters and performed genome-scale CRISPR-interference screens.