Harpreet Hyare

1 week ago | jnnp.bmj.com | Frederick Vonberg |Imran Malik |Maeve O’Reilly |Harpreet Hyare

ConclusionsCAR-T has already transformed the treatment of haematological malignancies and is poised to impact a range of other diseases. Though highly effective, CAR-T is hampered by toxicities, the most significant of which is currently ICANS.10 188 206 207 The landscape of CAR-T neurotoxicity is rapidly evolving as CAR-T is used in an expanding spectrum of contexts. MNT and TIAN are examples of more recently recognised CAR-T neurotoxicities.