Harry Benjamin Cutler

Mar 11, 2025 | biorxiv.org | Søren Anker Madsen |Kristen C. Cooke |Meg Potter |Harry Benjamin Cutler

AbstractLipids, in particular ceramides and diacylglycerols (DAGs), are implicated in insulin resistance, however their precise roles remain unclear. We leverage natural genetic variation to examine muscle lipids and systemic insulin resistance (IR) in 399 Diversity Outbred Australia mice. Adipose mass was associated with 55% of muscle lipids and IR, with DAGs as the only enriched lipid class.