Hartmut Schütze

Nov 13, 2024 | nature.com | Niklas Vockert |Luca Kleineidam |Hartmut Schütze |Renat Yakupov |Josef Priller |Anja Schneider | +11 more

AbstractThe cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. Here, we test this hypothesis in the continuum from cognitively normal to at-risk stages for Alzheimer’s Disease (AD) to AD dementia using longitudinal data from 490 participants of the DELCODE multicentric observational study. Brain function is measured using task fMRI of visual memory encoding.