Renat Yakupov

Nov 13, 2024 | nature.com | Niklas Vockert |Luca Kleineidam |Hartmut Schütze |Renat Yakupov |Josef Priller |Anja Schneider | +11 more

AbstractThe cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. Here, we test this hypothesis in the continuum from cognitively normal to at-risk stages for Alzheimer’s Disease (AD) to AD dementia using longitudinal data from 490 participants of the DELCODE multicentric observational study. Brain function is measured using task fMRI of visual memory encoding.

Jul 10, 2024 | medrxiv.org | Jose Bernal |Inga Menze |Renat Yakupov |Oliver Peters

The authors have declared no competing interest. This research was supported by the German Center for Neurodegenerative Diseases (DZNE; reference number BN012) and funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG; Project IDs 425899996 and 362321501/RTG 2413 SynAGE; CRC 1436, projects A05, B02, B04 and C01). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.