Heinrich Kovar

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YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells

Jul 18, 2024 | biorxiv.org | Aleksandr Bykov |Heinrich Kovar |Barbara Sax |Rahil Noorizadeh

AbstractEwing sarcoma (EwS) is an aggressive cancer of adolescents in need of effective treatments. Insulin like growth factor (IGF) 1 was previously reported an autocrine growth factor for EwS, but only 10% of patients responded to IGF-1 receptor blockade.

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