Helen S. Mayberg

Jul 25, 2024 | nature.com | Mathilde Antoniades |Stephen R. Arnott |Ki Sueng Choi |Benicio N. Frey |Melanie Ganz |Beata Godlewska | +18 more

Correction to: Nature Mental Health https://doi.org/10.1038/s44220-023-00187-w, published online 12 January 2024. In the version of the article initially published, the first affiliation of Melanie Ganz was incorrect and has now been amended to Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark in the HTML and PDF versions of the article.

Jun 27, 2024 | nature.com | Boadie W Dunlop |Helen S. Mayberg

Circuitry-based neuroimaging analyses can enhance our understanding of abnormal brain functioning in patients with major depressive disorder and other psychiatric conditions — but their utility for guiding treatment selection is less certain.

Feb 25, 2024 | nature.com | Seth R. Batten |Dan Bang |Arianna Davis |Matthew Heflin |Ignacio Saez |Terry Lohrenz | +6 more

AbstractDopamine and serotonin are hypothesized to guide social behaviours. In humans, however, we have not yet been able to study neuromodulator dynamics as social interaction unfolds. Here, we obtained subsecond estimates of dopamine and serotonin from human substantia nigra pars reticulata during the ultimatum game. Participants, who were patients with Parkinson’s disease undergoing awake brain surgery, had to accept or reject monetary offers of varying fairness from human and computer players.

Feb 10, 2024 | biologicalpsychiatryjournal.com | Martijn Figee |Ki Sueng Choi |Andrew Smith |Helen S. Mayberg

Deep brain stimulation (DBS) in the anterior limb of the internal capsule (ALIC) is an effective treatment for obsessive-compulsive disorder (OCD). However, without a clear anatomical stimulation target within the complex ALIC region, clinical benefits are variable and require long trial-and-error periods of parameter optimization. To facilitate ALIC DBS scalability and clinical implementation, we report a method for precision ALIC DBS targeting using patient-specific tractography.

Dec 27, 2023 | biorxiv.org | Melissa Reneaux |Helen S. Mayberg |Karl Friston |Dimitris Pinotsis

AbstractWe present a computational model that elucidates the interplay between inflammation, serotonin levels, and brain activity. The model delineates how inflammation impacts extracellular serotonin, while cerebral activity reciprocally influences serotonin concentration. Understanding the reciprocal interplay between the immune system and brain dynamics is important, as unabated inflammation can lead to relapsing depression.