Melissa Reneaux

Dec 27, 2023 | biorxiv.org | Melissa Reneaux |Helen S. Mayberg |Karl Friston |Dimitris Pinotsis

AbstractWe present a computational model that elucidates the interplay between inflammation, serotonin levels, and brain activity. The model delineates how inflammation impacts extracellular serotonin, while cerebral activity reciprocally influences serotonin concentration. Understanding the reciprocal interplay between the immune system and brain dynamics is important, as unabated inflammation can lead to relapsing depression.