Helle D. Ulrich

Jun 24, 2024 | nature.com | Lonnie P Swift |Lucy Henderson |Abimael Cruz-Migoni |Christian Renz |Helle D. Ulrich |Joseph A. Newman | +3 more

AbstractDNA double-strand breaks (DSBs), such as those produced by radiation and radiomimetics, are amongst the most toxic forms of cellular damage, in part because they involve extensive oxidative modifications at the break termini. Prior to completion of DSB repair, the chemically modified termini must be removed. Various DNA processing enzymes have been implicated in the processing of these dirty ends, but molecular knowledge of this process is limited.