Joseph A. Newman

Feb 14, 2025 | nature.com | Joseph A. Newman |Nergis Imprachim |Paul Clarke |Mohammad Hossain |Hans J. Oh |Paul Workman | +2 more

AbstractBrachyury is a transcription factor that plays an essential role in tumour growth of the rare bone cancer chordoma and is implicated in other solid tumours. Brachyury is minimally expressed in healthy tissues, making it a potential therapeutic target. Unfortunately, as a ligandless transcription factor, brachyury has historically been considered undruggable.

Jun 24, 2024 | nature.com | Lonnie P Swift |Lucy Henderson |Abimael Cruz-Migoni |Christian Renz |Helle D. Ulrich |Joseph A. Newman | +3 more

AbstractDNA double-strand breaks (DSBs), such as those produced by radiation and radiomimetics, are amongst the most toxic forms of cellular damage, in part because they involve extensive oxidative modifications at the break termini. Prior to completion of DSB repair, the chemically modified termini must be removed. Various DNA processing enzymes have been implicated in the processing of these dirty ends, but molecular knowledge of this process is limited.