Heran Zhang

Nov 13, 2024 | nature.com | Heran Zhang |Ian R. Monk |Claerwen M. Jones |Andrew Brooks |Timothy P. Stinear

AbstractSuperantigens (sAgs) are bacterial virulence factors that induce a state of immune hyperactivation by forming a bridge between certain subsets of T cell receptor (TCR) β chains on T lymphocytes, and class II major histocompatibility complex (MHC-II) molecules; this cross-linking leads to indiscriminate T cell activation, cytokine storm and toxic shock.