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Nov 13, 2024 | 
nature.com | Heran Zhang |Ian R. Monk |Claerwen M. Jones |Andrew Brooks |Timothy P. Stinear
AbstractSuperantigens (sAgs) are bacterial virulence factors that induce a state of immune hyperactivation by forming a bridge between certain subsets of T cell receptor (TCR) β chains on T lymphocytes, and class II major histocompatibility complex (MHC-II) molecules; this cross-linking leads to indiscriminate T cell activation, cytokine storm and toxic shock.
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Oct 23, 2024 | 
nature.com | Adrianna M Turner |Ian R. Monk |Danielle Ingle |Stephanie Portelli |Torsten Seemann |Liam Sharkey | +7 more
AbstractMultidrug-resistant bacterial pathogens like vancomycin-resistant Enterococcus faecium (VREfm) are a critical threat to human health1. Daptomycin is a last-resort antibiotic for VREfm infections with a novel mode of action2, but for which resistance has been widely reported but is unexplained. Here we show that rifaximin, an unrelated antibiotic used prophylactically to prevent hepatic encephalopathy in patients with liver disease3, causes cross-resistance to daptomycin in VREfm.
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Oct 1, 2024 | 
biorxiv.org | Marie-Christine Groleau |Abderrahman Hachani |Matthew P. Padula |Timothy P. Stinear
AbstractPhenotypic diversity in bacteria often results from adaptation to changing environmental conditions and is exemplified by variable colony morphotypes. Discrete genomic changes and modulation in gene expression occur in Burkholderia pseudomallei undergoing adaptation. Alternatively, adapted colony morphotype variants of species belonging to the Burkholderia cepacia complex (Bcc) lose a complete replicon (the pC3 virulence megaplasmid), which affects their production of virulence factors.
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Aug 11, 2024 | 
nature.com | Ian R. Monk |Ying-Tsun Cheng |Camilla Predella |Jack Boylan |Ahmed Moustafa |Gaurav Kumar Lohia | +5 more
AbstractStaphylococcus aureus is a pulmonary pathogen associated with substantial human morbidity and mortality. As vaccines targeting virulence determinants have failed to be protective in humans, other factors are likely involved in pathogenesis. Here we analysed transcriptomic responses of human clinical isolates of S. aureus from initial and chronic infections. We observed upregulated collagenase and proline transporter gene expression in chronic infection isolates.
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May 2, 2024 | 
preprints.org | Emma Hobbs |Timothy P. Stinear |Jessica Porter |Panos Loukopoulos
Preprint Case Report Version 1 This version is not peer-reviewed Version 1 : Received: 1 May 2024 / Approved: 1 May 2024 / Online: 2 May 2024 (12:04:22 CEST) Hobbs, E.C.; Loukopoulos, P.; Stinear, T.; Porter, J.; Lee, J.; Whiteley, P.; Skerratt, L.; Gibney, K.; Meredith, A. Severe Cases of Buruli Ulcer (Infection with Mycobacterium ulcerans) in Common Ringtail Possums in Victoria Are Adversely Affecting Animal Welfare. Preprints 2024, 2024050088.
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Apr 14, 2024 | 
nature.com | Peter Mee |Andrew H. Buultjens |Deborah A. Williamson |Kim Blasdell |Chris Sanders |Stuart Larsen | +6 more
Correction to: Nature Microbiology https://doi.org/10.1038/s41564-023-01553-1, published online 23 January 2024. In the version of the article initially published, Extended Data Tables 1–3 were missing. They have now been added to the HTML and PDF versions of the article.
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Jan 22, 2024 | 
nature.com | Peter Mee |Andrew H. Buultjens |Deborah A. Williamson |Kim Blasdell |Chris Sanders |Stuart Larsen | +6 more
AbstractBuruli ulcer, a chronic subcutaneous infection caused by Mycobacterium ulcerans, is increasing in prevalence in southeastern Australia. Possums are a local wildlife reservoir for M. ulcerans and, although mosquitoes have been implicated in transmission, it remains unclear how humans acquire infection. We conducted extensive field survey analyses of M. ulcerans prevalence among mosquitoes in the Mornington Peninsula region of southeastern Australia.
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Sep 30, 2023 | 
wwwnc.cdc.gov | Andrew H. Buultjens |Aidan Yuen |Timothy P. Stinear |N. Deborah Friedman
Loftus MJ, Tay EL, Globan M, Lavender CJ, Crouch SR, Johnson PDR, et al. Epidemiology of Buruli ulcer infections, Victoria, Australia, 2011–2016. Emerg Infect Dis. 2018;24:1988–97. DOIPubMedGoogle ScholarJohnson PDR, Azuolas J, Lavender CJ, Wishart E, Stinear TP, Hayman JA, et al. Mycobacterium ulcerans in mosquitoes captured during outbreak of Buruli ulcer, southeastern Australia. Emerg Infect Dis. 2007;13:1653–60.
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Aug 8, 2023 | 
biorxiv.org | Andrew H. Buultjens |Aidan Yuen |N Deborah Friedman |Timothy P. Stinear
New Results doi: https://doi.org/10.1101/2023.08.07.552371 AbstractRoss River Virus and Barmah Forest Virus infections (alphaviruses) have short incubation periods and are transmitted to humans by mosquitoes. Mycobacterium ulcerans infection (Buruli ulcer) has a much longer incubation period and its mode of transmission is contested.
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Mar 29, 2023 | 
biorxiv.org | Timothy P. Stinear |Jessica Porter |Anita Velink
New Results doi: https://doi.org/10.1101/2023.03.29.534673 AbstractIntroduction: Mycobacterium ulcerans (MU) causes Buruli ulcer (BU), a geographically restricted infection that can result in skin loss, contracture, and permanent scarring.
