Hiddo J. L

Sep 20, 2024 | academic.oup.com | Hiddo J. L |UNSW Sydney |Janssen Research |Spring House

Studies in patients with heart failure have indicated that sodium-glucose cotransporter 2 (SGLT2) inhibitors increase iron use and enhance erythropoiesis. In this post-hoc analysis of the CREDENCE trial, we evaluated the effects of canagliflozin on iron metabolism in patients with chronic kidney disease (CKD) and whether the effects of canagliflozin on hemoglobin and cardiorenal outcomes were modified by iron deficiency.

Aug 9, 2024 | academic.oup.com | Hiddo J. L

Clinical trials have demonstrated positive cardiovascular and kidney outcomes of sodium-glucose-co-transporter-2 (SGLT2) inhibitors in adult patients with diabetic and other chronic kidney diseases (CKD). Whether benefits extend to children, teenagers, and young adults with early-stage CKD is unknown.

Apr 22, 2024 | eprints.gla.ac.uk | Hiddo J. L

Denicolò, S. et al. (2024) Non-adherence to cardiometabolic medication as assessed by LC-MS/MS in urine and its association with kidney and cardiovascular outcomes in type 2 diabetes mellitus. Diabetologia, 67(7), pp. 1283-1294. (doi: 10.1007/s00125-024-06149-w) (PMID:38647650) (PMCID:PMC11153278) Text327652.pdf - Published Version Available under License Creative Commons Attribution.

Dec 14, 2023 | link.springer.com | John J.V |Anna Maria |Hiddo J. L

AbstractThe sodium-glucose cotransporter type 2 inhibitor dapagliflozin reduces the risk of progressive kidney disease and cardiovascular events in patients with chronic kidney disease, with and without type 2 diabetes. Whether its effects are uniform across the spectrum of age and among men and women is unknown. We performed a pre-specified analysis in DAPA-CKD to evaluate efficacy and safety of dapagliflozin according to baseline age and sex. Prospective randomized placebo-controlled trial.

Sep 17, 2023 | paperity.org | Hiddo J. L

European Journal of Pediatrics, Aug 2023 In adults, albuminuria represents a risk factor for cardiovascular disease and is associated with hypertension and obesity. Pediatric data from the general population are inconsistent and largely based on randomly collected urine. A possible association between antenatal programming and albuminuria at school age has still to be investigated.