Hiroyuki Nagashima

Nov 20, 2024 | nature.com | Hiroyuki Nagashima |Kan Jiang |Yuka Kanno |Justin Shayne

AbstractThe type 2 cytokines, interleukin (IL)-4, IL-13 and IL-5 reside within a multigene cluster. Both innate (ILC2) and adaptive T helper 2 (TH2) lymphocytes secrete type 2 cytokines with diverse production spectra. Using transcription factor footprint and chromatin accessibility, we systemically cataloged regulatory elements (REs) denoted as SHS-I/II, KHS-I/II, +6.5kbIl13, 5HS-I(a, b, c, d, e), 5HS-II and 5HS-III(a, b, c) across the extended Il4-Il13-Il5 locus in mice.

Nov 2, 2024 | biorxiv.org | Dominic P. Golec |Pedro Henrique Gazzinelli-Guimaraes |Pedro H. Gazzinelli-Guimarães |Daniel Chauss |Hiroyuki Nagashima

AbstractWhile inputs regulating CD4+ T helper cell (Th) differentiation are well-defined, the integration of downstream signaling with transcriptional and epigenetic programs that define Th-lineage identity remain unresolved. PI3K signaling is a critical regulator of T cell function; activating mutations affecting PI3Kδ result in an immunodeficiency with multiple T cell defects.

May 1, 2024 | cell.com | Chunhong Liu |Neuro-Immune Regulome Unit |Hiroyuki Nagashima |Skin Diseases

Cytokine expression during T cell differentiation is a highly regulated process that involves long-range promoter-enhancer and CTCF-CTCF contacts at cytokine loci.

Jun 29, 2023 | frontiersin.org | Liang Chen |Yuefeng Huang |Hiroyuki Nagashima |Luzheng Xue

IntroductionThe most common health problems associated with alcohol use disorder (AUD) include liver steatosis and cirrhosis (1, 2), cardiomyopathies (3) and nerve damage (i.e., neuropathies) (4). Recent evidence indicates that the lung is also adversely affected by alcohol abuse. Chronic alcohol ingestion may render the lung susceptible to fibrosis in the mouse model of bleomycin-induced acute lung injury (ALI) (5), pulmonary infections (6), and acute respiratory distress syndrome (ARDS) (7).