Hiroyuki Yoshihara

Jul 16, 2024 | nature.com | Kyuto Sonehara |Tatsuhiko Naito |Hiroyuki Yoshihara |Koichi Matsuda |Yukinori Okada

AbstractRecurrent pregnancy loss (RPL) is a major reproductive health issue with multifactorial causes, affecting 2.6% of all pregnancies worldwide. Nearly half of the RPL cases lack clinically identifiable causes (e.g., antiphospholipid syndrome, uterine anomalies, and parental chromosomal abnormalities), referred to as unexplained RPL (uRPL). Here, we perform a genome-wide association study focusing on uRPL in 1,728 cases and 24,315 female controls of Japanese ancestry.