Tatsuhiko Naito

Sep 20, 2024 | nature.com | Tatsuhiko Naito |Shinichi Namba |Kyuto Sonehara |Ken Suzuki |Biobank Japan |Koichi Matsuda | +2 more

AbstractAlthough polygenic risk scores (PRSs) are expected to be helpful in precision medicine, it remains unclear whether high-PRS groups are more likely to benefit from preventive interventions for diseases. Recent methodological advancements enable us to predict treatment effects at the individual level. We employed causal forest to explore the relationship between PRSs and individual risk of diseases associated with certain environmental factors.

Jul 16, 2024 | nature.com | Kyuto Sonehara |Tatsuhiko Naito |Hiroyuki Yoshihara |Koichi Matsuda |Yukinori Okada

AbstractRecurrent pregnancy loss (RPL) is a major reproductive health issue with multifactorial causes, affecting 2.6% of all pregnancies worldwide. Nearly half of the RPL cases lack clinically identifiable causes (e.g., antiphospholipid syndrome, uterine anomalies, and parental chromosomal abnormalities), referred to as unexplained RPL (uRPL). Here, we perform a genome-wide association study focusing on uRPL in 1,728 cases and 24,315 female controls of Japanese ancestry.

Jan 14, 2024 | nature.com | Tatsuhiko Naito |Yukinori Okada

AbstractThe imputation of unmeasured genotypes is essential in human genetic research, particularly in enhancing the power of genome-wide association studies and conducting subsequent fine-mapping. Recently, several deep learning-based genotype imputation methods for genome-wide variants with the capability of learning complex linkage disequilibrium patterns have been developed.

Oct 2, 2023 | nature.com | Tomohiro Miyai |Junshi Yazaki |Shinichi Namba |Tatsuhiko Naito |Eiryo Kawakami |Jun Seita | +5 more

AbstractAtopic dermatitis (AD) is a skin disease that is heterogeneous both in terms of clinical manifestations and molecular profiles. It is increasingly recognized that AD is a systemic rather than a local disease and should be assessed in the context of whole-body pathophysiology.