Hiruni S. Jayasekera

Oct 25, 2024 | biorxiv.org | Hiruni S. Jayasekera |Farhana Afrin Mohona |Katherine Miller |Michael Marty

AbstractLipids surrounding membrane proteins interact with different sites on the protein at varying specificities, ranging from highly specific to weak interactions. These interactions can modulate the structure, function, and stability of membrane proteins. Thus, to better understand membrane protein structure and function, it is important to identify the locations of lipid binding and the relative specificities of lipid binding at these sites.

Apr 1, 2024 | pubs.acs.org | Hiruni S. Jayasekera |Farhana Afrin Mohona |Megan A. Ewbank |Michael Marty

Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).

Apr 1, 2024 | dx.doi.org | Hiruni S. Jayasekera |Farhana Afrin Mohona |Megan A. Ewbank |Michael Marty

Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).

Sep 22, 2023 | biorxiv.org | Megan A. Ewbank |Michael Marty |Hiruni S. Jayasekera |Farhana Afrin Mohona

AbstractLipids are critical modulators of membrane protein structure and function. However, it is challenging to investigate the thermodynamics of protein-lipid interactions because lipids can simultaneously bind membrane proteins at different sites with different specificities. Here, we developed a native mass spectrometry (MS) approach using single and double mutants to measure the relative energetic contributions of specific residues on Aquaporin Z (AqpZ) toward cardiolipin (CL) binding.

May 18, 2023 | pubs.acs.org | Weijing Liu |Hiruni S. Jayasekera |James Sanders |Guozhi Zhang

Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).