Michael Marty

Oct 25, 2024 | biorxiv.org | Hiruni S. Jayasekera |Farhana Afrin Mohona |Katherine Miller |Michael Marty

AbstractLipids surrounding membrane proteins interact with different sites on the protein at varying specificities, ranging from highly specific to weak interactions. These interactions can modulate the structure, function, and stability of membrane proteins. Thus, to better understand membrane protein structure and function, it is important to identify the locations of lipid binding and the relative specificities of lipid binding at these sites.

May 14, 2024 | nature.com | Tanja Habeck |Kyle Brown |Mowei Zhou |Michael Volný |Jeffrey N. Agar |Ying Ge | +4 more

AbstractThe combination of native electrospray ionization with top-down fragmentation in mass spectrometry (MS) allows simultaneous determination of the stoichiometry of noncovalent complexes and identification of their component proteoforms and cofactors. Although this approach is powerful, both native MS and top-down MS are not yet well standardized, and only a limited number of laboratories regularly carry out this type of research.

Apr 1, 2024 | pubs.acs.org | Hiruni S. Jayasekera |Farhana Afrin Mohona |Megan A. Ewbank |Michael Marty

Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).

Apr 1, 2024 | dx.doi.org | Hiruni S. Jayasekera |Farhana Afrin Mohona |Megan A. Ewbank |Michael Marty

Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).

Jan 22, 2024 | elifesciences.org | Jixing Lyu |Tianqi Zhang |Michael Marty |David Clemmer

eLife assessment This is an important biophysical study combining native mass spectrometry with mutant cycles to estimate the thermodynamic components of lipid A binding to the ABC transporter MsbA. Solid evidence supports the binding energies for lipid-protein interactions to MsbA using this approach, which could be later applied to other membrane proteins in general.