Hlin Kvartsberg

Oct 16, 2024 | biorxiv.org | Katharina Waury |Hlin Kvartsberg |Henrik Zetterberg |Kaj Blennow

AbstractAntibodies are indispensable in laboratory and clinical applications due to their high specificity and affinity for protein antigens. However, selecting the right protein fragments as immunogens for antibody production remains challenging. Leveraging the Human Protein Atlas, this study systematically evaluates immunogen properties aiming to identify key factors that influence their suitability.

Oct 11, 2024 | biorxiv.org | Katharina Waury |Hlin Kvartsberg |Henrik Zetterberg |Kaj Blennow

AbstractAntibodies are indispensable in laboratory and clinical applications due to their high specificity and affinity for protein antigens. However, selecting the right protein fragments as immunogens for antibody production remains challenging. Leveraging the Human Protein Atlas, this study systematically evaluates immunogen properties aiming to identify key factors that influence their suitability.

Mar 22, 2024 | nature.com | Fernando Gonzalez-Ortiz |Maciej Dulewicz |Vijay R. Varma |Tammaryn Lashley |Gunnar Brinkmalm |Susan M. Resnick | +6 more

AbstractBlood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer’s disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally at threonine-212, but the contribution of p-tau212 alone to AD is unknown. We developed a blood-based immunoassay that is specific to p-tau212 without cross-reactivity to p-tau217. Here, we examined the diagnostic utility of plasma p-tau212.