Susan M. Resnick

Oct 4, 2024 | nature.com | Junhao Wen |Ilya M. Nasrallah |Guray Erus |Jingxuan Bao |Andrew J. Saykin |Timothy J. Hohman | +11 more

AbstractAlzheimer’s disease (AD) is associated with heterogeneous atrophy patterns. We employed a semi-supervised representation learning technique known as Surreal-GAN, through which we identified two latent dimensional representations of brain atrophy in symptomatic mild cognitive impairment (MCI) and AD patients: the “diffuse-AD” (R1) dimension shows widespread brain atrophy, and the “MTL-AD” (R2) dimension displays focal medial temporal lobe (MTL) atrophy.

Aug 15, 2024 | nature.com | Zhijian Yang |Junhao Wen |Guray Erus |Elizabeth Mamourian |Katharina Wittfeld |Duygu Tosun | +17 more

AbstractBrain aging process is influenced by various lifestyle, environmental and genetic factors, as well as by age-related and often coexisting pathologies. Magnetic resonance imaging and artificial intelligence methods have been instrumental in understanding neuroanatomical changes that occur during aging.

Jul 15, 2024 | reviewob.com | Susan M. Resnick

Enhancing eye health and  profitability through science-led nutraceutical solutions. Sponsored ContentBy Susan Resnick, OD, FAAO, FSLSJuly 17, 2024A few years after the AREDS studies were published, our practice decided to move to a more proactive approach for managing our patients’ macular health. The recognition of nutrition’s role in eye health provided by these studies evolved to include the prescription and sale of nutraceuticals.

Mar 22, 2024 | nature.com | Fernando Gonzalez-Ortiz |Maciej Dulewicz |Vijay R. Varma |Tammaryn Lashley |Gunnar Brinkmalm |Susan M. Resnick | +6 more

AbstractBlood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer’s disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally at threonine-212, but the contribution of p-tau212 alone to AD is unknown. We developed a blood-based immunoassay that is specific to p-tau212 without cross-reactivity to p-tau217. Here, we examined the diagnostic utility of plasma p-tau212.