Holger K. Eltzschig

Nov 30, 2023 | physoc.onlinelibrary.wiley.com | Thu Tran |Holger K. Eltzschig |Xiaoyi Yuan

Supporting Information Filename Description tjp15828-sup-0001-PeerReview.pdf2.8 MB Peer Review History References , , , , , , , , , , , , , , , , & (2015). Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunology, 8(6), 1324–1338. , , , , , , , & (2016). Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans. Nature Communications, 7(1), 10388. , , , & (1967).

Jul 3, 2023 | nature.com | Wei Ruan |Holger K. Eltzschig |Xiaoyi Yuan

The PHD–pVHL pathway is essential for oxygen-dependent prolyl hydroxylation of HIFA. A recent study identifies RIPK1 as a hydroxylation target in this pathway during hypoxia-induced cell death and presents a 2.8 Å resolution crystal structure of the pVHL–elongin B/C complex bound to hydroxylated RIPK1. Zhang et al.6 began by exploring the functional role of RIPK1 in hypoxia-induced cell death.

Mar 23, 2023 | nature.com | Ruoyu Wang |David M. Gilbert |Holger K. Eltzschig

Cell cultureHuman lung adenocarcinoma cells A549 expressing human ACE2 (A549-ACE2, NR-53821) were acquired from BEI Resources. They were maintained in DMEM/F-12 (1:1, Corning) medium supplemented with 10% FBS (GeneDepot) and blasticidin (100 μM). Normal A549 cells were purchased from ATCC (CCL-185) and cultured in DMEM/F-12 (1:1, Corning) supplemented with 10% FBS. 293T cells were from ATCC and were cultured in DMEM with 10% FBS.