Xiaoyi Yuan

Dec 20, 2023 | nature.com | Xiaoyi Yuan |Wei Ruan |Peter Carmeliet

AbstractHypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for adaptation of metazoans to limited oxygen availability. Recently, HIF activation and inhibition have emerged as therapeutic targets in various human diseases. Pharmacologically desirable effects of HIF activation include erythropoiesis stimulation, cellular metabolism optimization during hypoxia and adaptive responses during ischaemia and inflammation.

Nov 30, 2023 | physoc.onlinelibrary.wiley.com | Thu Tran |Holger K. Eltzschig |Xiaoyi Yuan

Supporting Information Filename Description tjp15828-sup-0001-PeerReview.pdf2.8 MB Peer Review History References , , , , , , , , , , , , , , , , & (2015). Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunology, 8(6), 1324–1338. , , , , , , , & (2016). Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans. Nature Communications, 7(1), 10388. , , , & (1967).

Jul 3, 2023 | nature.com | Wei Ruan |Holger K. Eltzschig |Xiaoyi Yuan

The PHD–pVHL pathway is essential for oxygen-dependent prolyl hydroxylation of HIFA. A recent study identifies RIPK1 as a hydroxylation target in this pathway during hypoxia-induced cell death and presents a 2.8 Å resolution crystal structure of the pVHL–elongin B/C complex bound to hydroxylated RIPK1. Zhang et al.6 began by exploring the functional role of RIPK1 in hypoxia-induced cell death.