Holly Chinnery

Sep 11, 2024 | nature.com | Xin Huang |Yijun Pan |Céline Dubois |Holly Chinnery |James D. Doecke |Yong Lin | +1 more

AbstractImpaired clearance of amyloid β (Aβ) in late-onset Alzheimer’s disease (AD) affects disease progression. The role of peripheral monocytes in Aβ clearance from the central nervous system (CNS) is unclear. We use a flow cytometry assay to identify Aβ-binding monocytes in blood, validated by confocal microscopy, Western blotting, and mass spectrometry. Flow cytometry immunophenotyping and correlation with AD biomarkers are studied in 150 participants from the AIBL study.

Aug 30, 2024 | nature.com | Mengliang Wu |Holly Chinnery |Laura E. Downie

AbstractBalanced immune responses in the eyes are crucial to preserve vision. The ocular immune system has long been considered distinct, owing to the so-called ‘immune privilege’ of its component tissues. More recently, intravital imaging and transcriptomic techniques have reshaped scientific understanding of the ocular immune landscape, such as revealing the specialization of immune cell populations in the various tissues of the eye.

Jul 18, 2023 | onlinelibrary.wiley.com | Mengliang Wu |Holly Chinnery |Laura E. Downie

Open Research The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. REFERENCES 1, , , . Efficacy of autologous serum tears for treatment of neuropathic corneal pain. Ocul Surf. 2019; 17: 532- 539. 2, , , , . Corneal nerves in health and disease. Prog Retin Eye Res. 2019; 73:100762. 3, , , et al.