Yijun Pan

Sep 11, 2024 | nature.com | Xin Huang |Yijun Pan |Céline Dubois |Holly Chinnery |James D. Doecke |Yong Lin | +1 more

AbstractImpaired clearance of amyloid β (Aβ) in late-onset Alzheimer’s disease (AD) affects disease progression. The role of peripheral monocytes in Aβ clearance from the central nervous system (CNS) is unclear. We use a flow cytometry assay to identify Aβ-binding monocytes in blood, validated by confocal microscopy, Western blotting, and mass spectrometry. Flow cytometry immunophenotyping and correlation with AD biomarkers are studied in 150 participants from the AIBL study.