Holly Sadler

Mar 4, 2024 | biorxiv.org | Holly Sadler |Pramila Rijal |Tiong Kit Tan |Alain Townsend

AbstractCurrent influenza vaccination approaches protect against specific viral strains, but do not consistently induce broad and long-lasting protection to the diversity of circulating influenza viruses. Single cycle viruses delivered to the respiratory tract may offer a promising solution as they safely express a diverse array of viral antigens by undergoing just one round of cell infection in their host and stimulate broadly protective resident memory T-cell responses in the lung.