Tiong Kit Tan

May 6, 2024 | nature.com | Rory A Hills |Tiong Kit Tan |Alexander Cohen |Jennifer R. Keeffe |Michelle Hill |Madeeha Afzal | +7 more

AbstractDefending against future pandemics requires vaccine platforms that protect across a range of related pathogens. Nanoscale patterning can be used to address this issue. Here, we produce quartets of linked receptor-binding domains (RBDs) from a panel of SARS-like betacoronaviruses, coupled to a computationally designed nanocage through SpyTag/SpyCatcher links.

Mar 4, 2024 | biorxiv.org | Holly Sadler |Pramila Rijal |Tiong Kit Tan |Alain Townsend

AbstractCurrent influenza vaccination approaches protect against specific viral strains, but do not consistently induce broad and long-lasting protection to the diversity of circulating influenza viruses. Single cycle viruses delivered to the respiratory tract may offer a promising solution as they safely express a diverse array of viral antigens by undergoing just one round of cell infection in their host and stimulate broadly protective resident memory T-cell responses in the lung.