Holly Walker

Sep 1, 2023 | cell.com | Molecular Bioscience |Holly Walker |James Brown |Mark Wilson

Highlights•Full-length secretory clusterin (CLU) is released to the cytosol during ER stress•The N-terminal CLU D1 residue and the enzyme ATE1 are required for CLU release to the cytosol•CLU can direct cytosolic misfolded proteins to the proteasome and autophagosomes•Cytosolic CLU can protect cells from stresses associated with cytosolic misfolded proteinsSummaryPrevious work suggests that cell stress induces release of the normally secreted chaperone clusterin (CLU) into the cytosol.

Mar 30, 2020 | glory.media | Holly Walker