James Brown

Sep 23, 2024 | nature.com | Enbo Zhu |Jiaji Yu |Yan-Ruide Li |Feiyang Ma |Yang Liu |James Brown | +2 more

AbstractChimeric antigen receptor (CAR)-engineered T cells represent a front-line therapy for cancers. However, the current CAR T cell manufacturing protocols do not adequately reproduce immunological synapse formation. Here, in response to this limitation, we have developed a flexible graphene oxide antigen-presenting platform (GO-APP) that anchors antibodies onto graphene oxide.

Jun 30, 2024 | rappnews.com | James Brown

Commentaries reflect the opinion of the writer(s), not the Rapp News. Comment below or by writing a letter to the editor: [email protected]. William Wordsworth said, “The child is father of the man.” William Faulkner said, “The past is never dead. It's not even past.” William Brown — my father — said, “Get up, boy. We’ve got places to go and things to do.” kA 5:ClQ=ECQmkDA2?mpE D@>6 A@:?E :? @FC =:G6D[ >@DE @7 FD 6IA6C:6?46 2 5:DD@?2?46 36EH66? E96 7@C46D E92E 5C:G6 @FC 564:D:@?D @?

Apr 16, 2024 | preprints.org | Christopher Collins |James Brown |Nathan Berkley

Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 12 April 2024 / Approved: 15 April 2024 / Online: 16 April 2024 (07:23:40 CEST) Collins, C.; Brown, J.; Berkley, N. MuhdoAge: A Novel Saliva Based Epigenetic Clock that Has a Strong Association with Ageing in a Healthy, Disease‐Free Cohort. Preprints 2024, 2024040985. https://doi.org/10.20944/preprints202404.0985.v1 Collins, C.; Brown, J.; Berkley, N.

Sep 1, 2023 | cell.com | Molecular Bioscience |Holly Walker |James Brown |Mark Wilson

Highlights•Full-length secretory clusterin (CLU) is released to the cytosol during ER stress•The N-terminal CLU D1 residue and the enzyme ATE1 are required for CLU release to the cytosol•CLU can direct cytosolic misfolded proteins to the proteasome and autophagosomes•Cytosolic CLU can protect cells from stresses associated with cytosolic misfolded proteinsSummaryPrevious work suggests that cell stress induces release of the normally secreted chaperone clusterin (CLU) into the cytosol.